abstract：:Primary microcephaly (PM) refers to a congenitally small brain, resulting from insufficient prenatal production of neurons, and serves as a model disease for brain volumic development. Known PM genes delineate several cellular pathways, among which the centriole duplication pathway, which provide interesting clues abo...

journal_title：Seminars in cell & developmental biology

authors： Duerinckx S,Abramowicz M

更新日期：2018-04-01 00:00:00

abstract：:The Endosomal Sorting Complex Required for Transport (ESCRT) proteins form an evolutionarily conserved membrane remodelling machinery. Identified originally for their role in cargo sorting and remodelling of endosomal membranes during yeast vacuolar sorting, an extensive body of work now implicates a sub-complex of th...

journal_title：Seminars in cell & developmental biology

authors： Stoten CL,Carlton JG

更新日期：2018-02-01 00:00:00

abstract：:During development cranial neural crest cells (NCCs) display a striking transition from collective to single-cell migration, but the mechanisms enabling individual NCCs to separate from the neural crest tissue are still incompletely understood. In this study we have employed atomic force microscopy (AFM) to investigat...

journal_title：Seminars in cell & developmental biology

authors： Blaue C,Kashef J,Franz CM

更新日期：2018-01-01 00:00:00

abstract：:With the arrival of atomic force microscopy (AFM) about thirty years ago, this new imaging tool opened up a new area for the exploration of biological samples, ranging from the tissue and cellular level down to the supramolecular scale. Commercial instruments of this new imaging technique began to appear in the five y...

journal_title：Seminars in cell & developmental biology

authors： Braet F,Taatjes DJ,Wisse E

更新日期：2018-01-01 00:00:00

abstract：:A wide range of cellular activities including protein folding and cell secretion, such as neurotransmission or insulin release, are all governed by intracellular pH homeostasis, underscoring the importance of pH on critical life processes. Nano- scale pH measurements of cells and biomolecules therefore hold great prom...

journal_title：Seminars in cell & developmental biology

authors： Lewis KT,Naik AR,Laha SS,Wang S,Mao G,Kuhn E,Jena BP

更新日期：2018-01-01 00:00:00

abstract：:Differences between sexes of the same species in lifespan and aging rate are widespread. While the proximal and evolutionary causes of aging are well researched, the factors that contribute to sex differences in these traits have been less studied. The striking diversity of nematodes provides ample opportunity to stud...

journal_title：Seminars in cell & developmental biology

authors： Ancell H,Pires-daSilva A

更新日期：2017-10-01 00:00:00

abstract：:Understanding how some animals are immortal and avoid the ageing process is important. We currently know very little about how they achieve this. Research with genetic model systems has revealed the existence of conserved genetic pathways and molecular processes that affect longevity. Most of these established model o...

journal_title：Seminars in cell & developmental biology

authors： Sahu S,Dattani A,Aboobaker AA

更新日期：2017-10-01 00:00:00

abstract：:Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true members of three protein families: plakins, spectrins and Gas2-like proteins. Spectraplakin genes encode at least 7 characteristic functional domains which are combined in a modular fashion into multiple isoforms, and which ar...

journal_title：Seminars in cell & developmental biology

authors： Voelzmann A,Liew YT,Qu Y,Hahn I,Melero C,Sánchez-Soriano N,Prokop A

更新日期：2017-09-01 00:00:00

abstract：:Clustered protocadherins mediate neuronal self-recognition and non-self discrimination-neuronal "barcoding"-which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compelling molecular mode...

journal_title：Seminars in cell & developmental biology

authors： Rubinstein R,Goodman KM,Maniatis T,Shapiro L,Honig B

更新日期：2017-09-01 00:00:00

abstract：:Spatial patterns of neuronal connectivity are critical for neural circuit function and information processing. For many neuron types, the development of stereotyped dendritic and axonal territories involves reiterative contacts between neurites and successive re-calibration of branch outgrowth and directionality. Here...

journal_title：Seminars in cell & developmental biology

authors： Lefebvre JL

更新日期：2017-09-01 00:00:00

abstract：:The nuclear pore complex (NPC) is the selective gateway through which all molecules must pass when entering or exiting the nucleus. It is a cog in the gene expression pathway, an entrance to the nucleus exploited by viruses, and a highly-tuned nanoscale filter. The NPC is a large proteinaceous assembly with a central ...

journal_title：Seminars in cell & developmental biology

authors： Stanley GJ,Fassati A,Hoogenboom BW

更新日期：2017-08-01 00:00:00

abstract：:Extracellular vesicles (EVs), lipid bilayer-enclosed structures that contain a variety of biological molecules shed by cells, are increasingly becoming appreciated as a major form of cell-to-cell communication. Indeed, EVs have been shown to play important roles in several physiological processes, as well as diseases ...

journal_title：Seminars in cell & developmental biology

authors： French KC,Antonyak MA,Cerione RA

更新日期：2017-07-01 00:00:00

abstract：:The vertebrate inner ear is a precision sensory organ, acting as both a microphone to receive sound and an accelerometer to detect gravity and motion. It consists of a series of interlinked, fluid-filled chambers containing patches of sensory epithelia, each with a specialised function. The ear contains many different...

journal_title：Seminars in cell & developmental biology

authors： Alsina B,Whitfield TT

更新日期：2017-05-01 00:00:00

abstract：:The identification of extensive genetic heterogeneity in human breast carcinomas poses a significant challenge for designing effective treatment regimens. Significant genomic evolution often occurs during breast cancer progression, creating variability within primary tumors as well as between the primary carcinoma and...

journal_title：Seminars in cell & developmental biology

authors： Ellsworth RE,Blackburn HL,Shriver CD,Soon-Shiong P,Ellsworth DL

更新日期：2017-04-01 00:00:00

abstract：:The use of the adapted models to decipher patho-physiological mechanisms of human diseases is always a great challenge. This is of particular importance for early-onset myopathies, in which pathological mutations often impact not only on muscle structure and function but also on developmental processes. Mice are curre...

journal_title：Seminars in cell & developmental biology

authors： Jagla K,Kalman B,Boudou T,Hénon S,Batonnet-Pichon S

更新日期：2017-04-01 00:00:00

abstract：:Genomic instability resultant from defective DNA repair mechanisms is a fundamental hallmark of cancer. The poly(ADP-ribose) polymerase (PARP) proteins 1, 2 and 3 catalyze the polymerization of poly(ADP-ribose) and covalent attachment to proteins in a phylogenetically ancient form of protein modification. PARPs play a...

journal_title：Seminars in cell & developmental biology

authors： Dulaney C,Marcrom S,Stanley J,Yang ES

更新日期：2017-03-01 00:00:00

abstract：:The intestine has long been studied as a model for adult stem cells due to the life-long self-renewal of the intestinal epithelium through the proliferation of the adult intestinal stem cells. Recent evidence suggests that the formation of adult intestinal stem cells in mammals takes place during the thyroid hormone-d...

journal_title：Seminars in cell & developmental biology

authors： Fu L,Shi YB

更新日期：2017-03-01 00:00:00

abstract：:Precise control of neural progenitor transformation into neural crest stem cells ensures proper craniofacial and head development. In the neural progenitor pool, SoxB factors play an essential role as cell fate determinants of neural development, whereas during neural crest stem cell formation, Sox2 plays a predominan...

journal_title：Seminars in cell & developmental biology

authors： Mandalos NP,Remboutsika E

更新日期：2017-03-01 00:00:00

abstract：:In mammals, sex determination defines the differentiation of the bipotential genital ridge into either testes or ovaries. Sry, the mammalian Y-chromosomal testis-determining gene, is a master regulator of male sex determination. It acts to switch the undifferentiated genital ridge towards testis development, triggerin...

journal_title：Seminars in cell & developmental biology

authors： She ZY,Yang WX

更新日期：2017-03-01 00:00:00

abstract：:The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and ben...

journal_title：Seminars in cell & developmental biology

authors： Hou L,Srivastava Y,Jauch R

更新日期：2017-03-01 00:00:00

abstract：:Human SERPINB3 and SERPINB4 are evolutionary duplicated serine/cysteine protease inhibitors. Genomic analysis indicates that these paralogous genes were encoded from independent loci arising from tandem gene duplication. Although the two molecules share 92% identity of their amino acid sequences, they are distinct in ...

journal_title：Seminars in cell & developmental biology

authors： Sun Y,Sheshadri N,Zong WX

更新日期：2017-02-01 00:00:00

abstract：:In addition to their established roles in host defence, Toll-like Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well a...

journal_title：Seminars in cell & developmental biology

authors： Ramnath D,Powell EE,Scholz GM,Sweet MJ

更新日期：2017-01-01 00:00:00

abstract：:Inflammation is a natural part of wound healing but it can also cause secondary (bystander) damage and/or negatively interfere with endogenous repair mechanisms if non-resolving. Regulation of inflammation is traditionally looked at from the perspective of danger signals, cytokines and chemokines, and their respective...

journal_title：Seminars in cell & developmental biology

authors： Jung WC,Levesque JP,Ruitenberg MJ

更新日期：2017-01-01 00:00:00

abstract：:Rhomboids are conserved intramembrane serine proteases with widespread functions. They were the earliest discovered members of the wider rhomboid-like superfamily of proteases and pseudoproteases. The secretase class of rhomboid proteases, distributed through the secretory pathway, are the most numerous in eukaryotes,...

journal_title：Seminars in cell & developmental biology

authors： Lastun VL,Grieve AG,Freeman M

更新日期：2016-12-01 00:00:00

abstract：:Influenza viral particles are enveloped by a lipid bilayer. A major step in infection is fusion of the viral and host cellular membranes, a process with large kinetic barriers. Influenza membrane fusion is catalyzed by hemagglutinin (HA), a class I viral fusion protein activated by low pH. The exact nature of the HA c...

journal_title：Seminars in cell & developmental biology

authors： Blijleven JS,Boonstra S,Onck PR,van der Giessen E,van Oijen AM

更新日期：2016-12-01 00:00:00

abstract：:Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, me...

journal_title：Seminars in cell & developmental biology

authors： Wang Y,Li L,Hou C,Lai Y,Long J,Liu J,Zhong Q,Diao J

更新日期：2016-12-01 00:00:00

abstract：:The purpose of this review is to describe the endocrine and local testicular factors that contribute to the regulation of the blood-testis barrier (BTB), using information gained from in vivo and in vitro models of BTB formation during/after puberty, and from the maintenance of BTB function during adulthood. In vivo t...

journal_title：Seminars in cell & developmental biology

authors： Stanton PG

更新日期：2016-11-01 00:00:00

abstract：:Indiscriminate use of synthetic chemical compounds and the unregulated presence of heavy metals threatens the integral reproducibility of mankind and other living organisms. The toxicity of these compounds far outweighs the usefulness of these compounds. Male reproductive health is linked to the process of spermatogen...

journal_title：Seminars in cell & developmental biology

authors： Jenardhanan P,Panneerselvam M,Mathur PP

更新日期：2016-11-01 00:00:00

abstract：:Myocardial infarction results in scar tissue that cannot actively contribute to heart mechanical function and frequently causes lethal arrhythmias. The healing response after infarction involves inflammation, biochemical signaling, changes in cellular phenotype, activity, and organization, and alterations in electrica...

journal_title：Seminars in cell & developmental biology

authors： Ongstad EL,Gourdie RG

更新日期：2016-10-01 00:00:00

abstract：:Large-scale identification of elements associated with gene expression revealed that many of them are located extremely far from gene transcriptional start sites. We review here the growing evidence that show that distal cis-acting elements provide key instructions to genes, as genetic variation affecting them is grow...

journal_title：Seminars in cell & developmental biology

authors： Spitz F

更新日期：2016-09-01 00:00:00

abstract：:X inactivation, a developmental process that takes place in early stages of mammalian embryogenesis, balances the sex difference in dosage of X-linked genes. Although all mammals use this form of dosage compensation, the details differ from one species to another because of variations in the staging of embryogenesis a...

journal_title：Seminars in cell & developmental biology

authors： Migeon BR

更新日期：2016-08-01 00:00:00

abstract：:The sculpting of embryonic tissues and organs into their functional morphologies involves the spatial and temporal regulation of mechanics at cell and tissue scales. Decades of in vitro work, complemented by some in vivo studies, have shown the relevance of mechanical cues in the control of cell behaviors that are cen...

journal_title：Seminars in cell & developmental biology

authors： Campàs O

更新日期：2016-07-01 00:00:00

abstract：:Cancer cachexia is a complex syndrome generated by interaction between the host and tumour cells with a background of treatment effects and toxicity. The complexity of the physiological pathways likely involved in cancer cachexia necessitates a holistic view of the relevant biology. Emergent properties are characteris...

journal_title：Seminars in cell & developmental biology

authors： Gallagher IJ,Jacobi C,Tardif N,Rooyackers O,Fearon K

更新日期：2016-06-01 00:00:00

abstract：:Cleavage furrow in animal cell cytokinesis is formed by cortical constriction driven by contraction of an actomyosin network activated by Rho GTPase. Although the role of the mitotic apparatus in furrow induction has been well established, there remain discussions about the detailed molecular mechanisms of the cleavag...

journal_title：Seminars in cell & developmental biology

authors： Mishima M

更新日期：2016-05-01 00:00:00

abstract：:We describe in this review increasing evidence that loss of LKB1 kinase in Peutz-Jeghers syndrome (PJS) derails the existing natural balance between cell survival and tumour growth suppression. LKB1 deletion can plunge cells into an energy/oxidative stress-induced crisis which leads to the activation of alternative an...

journal_title：Seminars in cell & developmental biology

authors： Shorning BY,Clarke AR

更新日期：2016-04-01 00:00:00

abstract：:By the development of information theory in 1948 by Claude Shannon to address the problems in the field of data storage and data communication over (noisy) communication channel, it has been successfully applied in many other research areas such as bioinformatics and systems biology. In this manuscript, we attempt to ...

journal_title：Seminars in cell & developmental biology

authors： Mousavian Z,Díaz J,Masoudi-Nejad A

更新日期：2016-03-01 00:00:00

abstract：:Gap junctions and hemichannels comprised of connexins influence epidermal proliferation and differentiation. Significant advances in our understanding of the functional role of connexins in the skin have been made by studying the diseases caused by connexin mutations. Eleven clinically defined cutaneous disorders with...

journal_title：Seminars in cell & developmental biology

authors： Lilly E,Sellitto C,Milstone LM,White TW

更新日期：2016-02-01 00:00:00

abstract：:The notion of feedback is fundamental for understanding signal transduction networks. Feedback loops attenuate or amplify signals, change the network dynamics and modify the input-output relationships between the signal and the target. Negative feedback provides robustness to noise and adaptation to perturbations, but...

journal_title：Seminars in cell & developmental biology

authors： Nguyen LK,Kholodenko BN

更新日期：2016-02-01 00:00:00

abstract：:Gap junctions are highly ordered plasma membrane domains that are constantly assembled, remodeled and turned over due to the short half-life of connexins, the integral membrane proteins that form gap junctions. Connexin 43 (Cx43), by far the most widely expressed connexin, is phosphorylated at multiple serine residues...

journal_title：Seminars in cell & developmental biology

authors： Solan JL,Lampe PD

更新日期：2016-02-01 00:00:00

abstract：:The proinflammatory cytokine tumor necrosis factor (TNF) orchestrates complex multicellular processes through a wide variety of changes that it induces in cell functions. At various stages of the study of TNF, attention has been drawn to one of three different modes of its action. The work that led to the discovery of...

journal_title：Seminars in cell & developmental biology

authors： Wallach D

更新日期：2016-02-01 00:00:00